The Health Benefits
of Fish Oil Omega-3 Essential Fatty Acids
Research has revealed
the importance of fish oil omega-3 essential fatty
acids (EPA/DHA). Numerous studies have indicated fish
oils play an important role for many aspects of health,
including:
CARDIOVASCULAR HEALTH
Studies suggest that fish oil promotes
healthy lipid and triglyceride metabolism, blood flow,
vascular dilation and tone, platelet function, endothelial
function, and erythrocyte membrane composition. Research
also suggests the potential for fish oil to contribute
to healthy homocysteine metabolism. Furthermore, fish
oil may help to protect the cardiovascular system
from the effects of occasional stress. In a recent
meta-analysis of 11 trials involving over 15,000 subjects,
fish oil was associated with providing overall cardiovascular
benefit.*
JOINT FUNCTION
Fish oil acts in part by maintaining
healthy prostaglandin, cytokine and leukotriene production,
supporting connective tissue and cartilage integrity.
It also plays a role in moderating neutrophil activity,
supporting joint comfort. Numerous small double blind
trials indicate that the omega-3 fatty acids in fish
oil promote joint motility and joint comfort. Another
double blind, placebo–controlled, prospective
study revealed that fish oil modulates immune mediator
activity as well as provides support for joint flexibility.*
COGNITIVE/EMOTIONAL HEALTH
(ADULTS)
Omega-3 fatty acids are important components
of neuronal cell membranes and are essential to cognitive
function. By supporting vascular health, fish oils
promote oxygen and nutrient delivery to the brain.
Studies suggest that healthy red blood cell membrane
omega-3 fatty acid concentration is associated with
emotional well-being. Both epidemiological and double
blind placebo-controlled trials indicate that fish
oil supports positive mood. Furthermore, dietary intake
of omega-3 fatty acids in adults has been associated
with maintaining healthy EPA/DHA serum levels as well
as a healthy EPA to arachidonic acid ratio, providing
potential support for mental function.*
COGNITIVE/VISUAL DEVELOPMENT
(CHILDREN)
Fish oil promotes healthy mental function
and maturation of the central nervous system, including
support for cell health and neurotransmission. Essential
fatty acids are also vital constituents of the retina,
helping to support healthy visual function. EPA and
DHA consumption by breast fed infants and children
born to mothers who supplement with fish oils has
demonstrated support for visual acuity and cognitive
development. A longitudinal study suggests that infants
born to mothers with higher DHA status demonstrated
healthy cognitive capacity at 12 and 18 months. A
randomized double blind study suggested that 4 year
olds born to mothers who had taken fish oil had healthy
cognitive function. Another study suggested that fish
oil supplementation may enhance healthy night vision
in children. Several studies have also revealed a
relationship between dietary omega-3 fatty acids,
healthy brain function and sleep patterns.*
RESPIRATORY FUNCTION
Fish oil has demonstrated the potential
to support bronchial smooth muscle function by moderating
leukotriene and interleukin production. Double blind
randomized studies indicate that fish oil supplementation
may promote healthy respiratory function in children
and adults. Another randomized controlled trial involving
10 elite athletes suggests that fish oil supplementation
encourages healthy post-exercise pulmonary function.*
IMMUNE RESPONSE
Essential fatty acids appear to exert
a beneficial effect on the immune response by maintaining
healthy cytokine activity at the level of gene expression.*
GASTROINTESTINAL HEALTH
Fish oil supplementation has been associated
with a soothing effect for the gastrointestinal (GI)
tract. In a double blind, placebo-controlled crossover
trial, subjects experienced positive support for GI
comfort. A separate 6 month trial revealed that fish
oil supplementation maintained healthy leukotriene
production and immune cell activity in the colon.*
SKIN HEALTH
Fish oils promote vascular health, supporting
oxygen and nutrient delivery to the skin. Studies
have shown that omega-3 fatty acids protect keratinocytes
and fibroblasts from free radicals and immune mediators
generated by sun exposure, helping to soothe the skin.
Additionally, they help promote elasticity and hydration
for smoother looking skin.*
References
Kris-Etherton P, Harris W, Appel L.
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and
Cardiovascular Disease. Circulation. 2002;106:2747.
Volker D, Fitzgerald P, Major G, Garg M. Efficacy
of fish oil concentrate in the treatment of rheumatoid
arthritis. J Rheumatol. 2000 Oct;27(10):2343-6.
Kremer JM, Lawrence DA, et al. Effects of high-dose
fish oil on rheumatoid arthritis after stopping nonsteroidal
antiinflammatory drugs. Clinical and immune correlates.
Arthritis Rheum. 1995 Aug;38(8):1107-14.
Sundrarjun T, Komindr S, Archararit N, et al. Effects
of n-3 fatty acids on serum interleukin-6, tumour
necrosis factor-alpha and soluble tumour necrosis
factor receptor p55 in active rheumatoid arthritis.
J Int Med Res. 2004 Sep-Oct;32(5):443-54.
Khan F, Elherik K, Bolton-Smith C, Barr R, et al.
The effects of dietary fatty acid supple-mentation
on endothelial function and vascular tone in healthy
subjects. Cardiovasc Res. 2003 Oct 1;59(4):955-62.
Thies F, Garry JM, Yaqoob P, et al. Association of
n-3 polyunsaturated fatty acids with stability of
atherosclerotic plaques: a randomised controlled trial.
Lancet. 2003 Feb 8;361(9356):477-85.
Nestel P, Shige H, Pomeroy S, et al. The n-3 fatty
acids eicosapentaenoic acid and docosa-hexaenoic acid
increase systemic arterial compliance in humans. Am
J Clin Nutr. 2002 Aug;76(2):326-30.
Chan DC, Watts GF, Mori TA, et al. Randomized controlled
trial of the effect of n-3 fatty acid supplementation
on the metabolism of apolipoprotein B-100 and chylomicron
remnants in men with visceral obesity. Am J Clin Nutr.
2003 Feb;77(2):300-7.
von Schacky C, Angerer P, Kothny W, et al. The effect
of dietary omega-3 fatty acids on coronary atherosclerosis.
A randomized, double-blind, placebo-controlled trial.
Ann Intern Med. 1999 Apr ;130(7):554-62.
Miyajima T, Tsujino T, Saito K, Yokoyama M. Effects
of eicosapentaenoic acid on blood pressure, cell membrane
fatty acids, and intracellular sodium concentration
in essential hypertension. Hypertens Res. 2001 Sep;24(5):537-42.
Tagawa T, Hirooka Y, Shimokawa H, et al. Long-term
treatment with eicosapentaenoic acid improves exercise-induced
vasodilation in patients with coronary artery disease.
Hypertens Res. 2002;25(6):823-9.
Hamazaki T, Sawazaki S, Itomura M, et al. The effect
of docosahexaenoic acid on aggression in young adults.
A placebo-controlled double-blind study. J Clin Invest.
1996 Feb 15;97(4):1129-33.
Bucher HC, Hengstler P, Schindler C, Meier G. N-3
polyunsaturated fatty acids in coronary heart disease:
a meta-analysis of randomized controlled trials. Am
J Med. 2002 Mar;112(4):298-304.
Grundt H, Nilsen DW, Mansoor MA, Hetland O, Nordoy
A. Reduction in homocysteine by n-3 polyunsaturated
fatty acids after 1 year in a randomised double-blind
study following an acute myocardial infarction: no
effect on endothelial adhesion properties. Pathophysiol
Haemost Thromb. 2003 Mar-12
Young GS, Conquer JA, Thomas R. Effect of randomized
supplementation with high dose olive, flax or fish
oil on serum phospholipid fatty acid levels in adults
with attention deficit hyperactivity disorder. Reprod
Nutr Dev. 2005 Sep-Oct;45(5):549-58.
Stevens LJ, Zentall SS, Abate ML, Kuczek T, Burgess
JR. Omega-3 fatty acids in boys with behavior, learning,
and health problems. Physiol Behav. 1996 Apr-May;59(4-5):915-20.
Dunstan JA, Mori TA, Barden A, et al. Fish oil supplementation
in pregnancy modifies neonatal allergen-specific immune
responses and clinical outcomes in infants at high
risk of atopy: a randomized, controlled trial. J Allergy
Clin Immunol. 2003 Dec;112(6):1178-84.
Mickleborough TD, Murray RL, Ionescu AA, Lindley MR.
Fish oil supplementation reduces severity of exercise-induced
bronchoconstriction in elite athletes. Am J Respir
Crit Care Med. 2003 Nov;168(10):1181-9.
Dry J, Vincent D. Effect of a fish oil diet on asthma:
results of a 1-year double-blind study. Int Arch Allergy
Appl Immunol. 1991;95(2-3):156-7.
Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata
K. Dietary supplementation with fish oil rich in omega-3
polyunsaturated fatty acids in children with bronchial
asthma. Eur Respir J. 2000 Nov;16(5):861-5.
Colombo J, Kannass KN, Shaddy DJ, et al. Maternal
DHA and the development of attention in infancy and
toddlerhood. Child Dev. 2004 Jul-Aug;75(4):1254-67.
Helland IB, Smith L, Saarem K, Saugstad OD, Drevon
CA. Maternal supplementation with very-long-chain
n-3 fatty acids during pregnancy and lactation augments
children's IQ at 4 years of age. Pediatrics. 2003
Jan;111(1):e39-44.
Uauy R, Hoffman DR, Peirano P, Birch DG, Birch EE.
Essential fatty acids in visual and brain development.
Lipids. 2001 Sep;36(9):885-95.
Wallace FA, Miles EA, Evans C, et al. Dietary fatty
acids influence the production of Th1-but not Th2-type
cytokines. J Leukoc Biol. 2001 Mar;69(3):449-57.
Rangi SP, Serwonska MH, Lenahan GA, et al. Suppression
by ingested eicosapentaenoic acid of the increases
in nasal mucosal blood flow and eosinophilia of ryegrass-allergic
reactions. J Allergy Clin Immunol. 1990 Feb;85(2):484-9.
Aslan A, Triadafilopoulos G. Fish oil fatty acid supplementation
in active ulcerative colitis: a double-blind, placebo-controlled,
crossover study. Am J Gastroenterol. 1992 Apr;87(4):432-7.
Almallah YZ, El-Tahir A, Heys SD, Richardson S, Eremin
O. Distal procto-colitis and n-3 polyunsaturated fatty
acids: the mechanism(s) of natural cytotoxicity inhibition.
Eur J Clin Invest. 2000 Jan;30(1):58-65.
Storey A, McArdle F, Friedmann PS, Jackson MJ, Rhodes
LE. Eicosapentaenoic acid and docosahexaenoic acid
reduce UVB- and TNF-alpha-induced IL-8 secretion in
keratinocytes and UVB-induced IL-8 in fibroblasts.
J Invest Dermatol. 2005 Jan;124(1):248-55.
For educational purposes only. Consult
your physician for any health problems.
*These statements have not been evaluated
by the Food & Drug Administration. This product
is not intended to diagnose, treat, cure or prevent
any disease.